Effects of methotrexate and cytosine arabinoside on polyamine metabolism in a mouse L1210 leukemia.
نویسنده
چکیده
The effects of methotrexate and cytosine arabinoside on polyamine metabolism were studied in a rapidly proliferating leukemic tumor (LI210) in C57BL/6 X DBA/2 (hereafter called BDP!) mice. Methotrexate, the most effective antileukemic drug in terms of increasing the median survival time also was the most effective, both in inhibiting the enzymes in the polyamine biosynthetic pathway and in decreasing the accumulation of polyamines by the tumor cells.
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The following mouse strains were used: C57BL/6 x DBA2 F1 (hereafter called BD2F1), 6 to 10 weeks old (A. R. Schmidt Co., Madison, Wis.), AKR/J, and C57BL/6J (The Jackson Laboratory, Bar Harbor, Maine). All groups con sisted of 5 or 10 male mice. The mouse neoplasms studied were the parental line L1210 and sublines ofLl2lO resistant to methotrexate and 6-methylmercaptopurineriboside; L5178Y and ...
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عنوان ژورنال:
- Cancer research
دوره 32 11 شماره
صفحات -
تاریخ انتشار 1972